The surgery has left Ms O’Connell unable to sweat from the neck down, meaning she finds hot weather extremely difficult as she can faint in the heat.
The Duke of York claimed in 2019 that due to an “overdose of adrenaline” during his time serving in the Falklands War, he found it “almost impossible” to perspire.
He was responding to allegations from Virginia Giuffre that he had sex with her in 2001 when she was 17 and sweated profusely during the encounter.
Andrew has vehemently denied all allegations against him.
Ms O’Connell hit back at Andrew’s words, saying: “Your body has to sweat or you die – we were laughing at the audacity of Prince Andrew.
“It was so infuriating – it’s like saying, ‘My body forgot how to breathe’.
“Sweating is such an issue that I can’t be out when it’s too hot as my body can’t function and I black out.”
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She continued: “It’s a lifelong journey with no end to this, it’s a battle of finding new ways to cope and deal with it.
“While I was getting used to it there were times when I blacked out in the street – my daughter is a young carer and as a family we’ve had to figure out ways to deal with this.”
Ms O’Connell was first diagnosed in 2009 having suffered symptoms since puberty, with the acne medication Roaccutane failing to treat her illness.
Another flare-up followed in 2012 after the birth of her son and her dermatologist suggested that an operation would be necessary, with Ms O’Connell going under the knife in 2013 to remove the sweat glands, lymph nodes and hair follicles under her left armpit.
Further surgery in 2014 and 2017 followed, with Ms O’Connell now adjusting to life being unable to sweat properly.
She said: “There’s not any rhyme or reason to the flare-ups. My body took a long time to adjust, I’d say I’m still adjusting now – I go from alright to really really hot really fast.
“It’s not actually that rare but when you have them on your boobs, groin and armpits, no one wants to talk about it.
“My mental health is the main thing, but it’s so physically painful because it’s in all the places you have high levels of movement.”